{
  "serviceId": "pmic-pharma-signals",
  "displayName": "PMIC Pharma Safety and Approval Signals",
  "description": "Scored drug-market and company safety briefs from openFDA, FDA, BLS and ClinicalTrials.gov: recalls, adverse events, approvals, trial pipelines, shortages, device safety, warning letters and drug prices, for the US market and for Pfizer, Lilly and J&J. Each is a 0-100 score with drivers and citations. POST /v1/brief with {vertical}. Research signal, not medical or investment advice.",
  "category": "health",
  "resourceUrl": "https://test.agent.pocket.network/v1/pmic-pharma-signals",
  "priceUsd": "0.005000",
  "priceVersion": 1,
  "rails": [
    {
      "id": "base",
      "network": "eip155:84532",
      "chainId": 84532,
      "tokenAddress": "0x036CbD53842c5426634e7929541eC2318f3dCF7e",
      "tokenDecimals": 6,
      "payToAddress": "0xF732ea490c5766071785a2310523f7fA2CEbB829"
    }
  ],
  "paymentNetworks": [
    "eip155:84532"
  ],
  "paymentProtocols": [
    "x402"
  ],
  "protocols": [
    "rest"
  ],
  "inputSchema": {
    "type": "object",
    "description": "The body of POST /v1/brief; company-safety and clinical-pipeline also need entity_id. The other routes take JSON bodies too: /v1/verticals takes {}; /v1/overview takes entity_id and horizon; /v1/signals takes source_id, horizon, sort, direction, min_confidence and limit; /v1/signal and /v1/explain take series_id; /v1/catalog takes entity_id and q; /v1/events takes entity_id, event_type, severity, since and limit.",
    "properties": {
      "vertical": {
        "type": "string",
        "enum": [
          "drug-market",
          "company-safety",
          "clinical-pipeline",
          "drug-shortages",
          "device-safety",
          "drug-prices",
          "fda-enforcement"
        ],
        "description": "Which brief to score."
      },
      "entity_id": {
        "type": "string",
        "enum": [
          "pfe",
          "lly",
          "jnj"
        ],
        "description": "The drug maker, for the company verticals."
      },
      "horizon": {
        "type": "string",
        "enum": [
          "7d",
          "30d",
          "90d",
          "365d"
        ],
        "description": "The window the trend is measured over."
      }
    },
    "required": [
      "vertical"
    ]
  },
  "outputSchema": {
    "type": "object",
    "properties": {
      "service": {
        "type": "string"
      },
      "pack_version": {
        "type": "string"
      },
      "vertical": {
        "type": "string"
      },
      "title": {
        "type": "string"
      },
      "question": {
        "type": "string"
      },
      "entity": {
        "description": "The company ({entity_id, name, ...}) on company briefs; absent otherwise."
      },
      "horizon": {
        "type": "string"
      },
      "status": {
        "type": "string",
        "enum": [
          "ok",
          "insufficient_data"
        ]
      },
      "score": {
        "description": "Integer 0-100, or null when status is insufficient_data."
      },
      "label": {
        "description": "The vertical's label for the score, or null with no score."
      },
      "trend": {
        "type": "string"
      },
      "trend_basis": {
        "description": "score_history, input_trends, or null when there is no trend."
      },
      "summary": {
        "type": "string"
      },
      "drivers": {
        "type": "array",
        "items": {
          "type": "object"
        }
      },
      "risk_flags": {
        "type": "array",
        "items": {
          "type": "string"
        }
      },
      "confidence": {
        "type": "object",
        "properties": {
          "score": {
            "type": "integer"
          },
          "label": {
            "type": "string"
          }
        }
      },
      "inputs": {
        "type": "array",
        "items": {
          "type": "object"
        }
      },
      "watch": {
        "type": "array",
        "items": {
          "type": "object"
        }
      },
      "recent_events": {
        "type": "array",
        "items": {
          "type": "object"
        }
      },
      "citations": {
        "type": "array",
        "items": {
          "type": "object",
          "properties": {
            "url": {
              "type": "string"
            },
            "label": {
              "type": "string"
            }
          }
        }
      }
    },
    "description": "The answer to POST /v1/brief. score, label and trend_basis are null on insufficient_data briefs; entity is an object on company briefs. Errors return {error: {code, message}} with HTTP 400; other routes return their own JSON objects (see the openapi spec)."
  },
  "methods": {
    "GET /v1/health": "read",
    "GET /v1/version": "read",
    "POST /v1/brief": "read",
    "POST /v1/catalog": "read",
    "POST /v1/events": "read",
    "POST /v1/explain": "read",
    "POST /v1/overview": "read",
    "POST /v1/signal": "read",
    "POST /v1/signals": "read",
    "POST /v1/verticals": "read"
  },
  "example": {
    "method": "POST",
    "path": "/v1/brief",
    "request": {
      "vertical": "company-safety",
      "entity_id": "lly",
      "horizon": "365d"
    },
    "response": {
      "portal": {
        "provenance": "third-party-supplier",
        "serviceId": "pmic-pharma-signals",
        "schemaCheck": "unchecked"
      },
      "data": {
        "service": "pmic-pharma-signals",
        "pack_version": "0.5.0",
        "vertical": "company-safety",
        "title": "Company drug safety",
        "question": "Are safety signals rising for this drug maker, and what has the FDA reported lately?",
        "entity": {
          "entity_id": "lly",
          "name": "Eli Lilly and Co.",
          "ticker": "LLY",
          "industry": "pharma"
        },
        "horizon": "365d",
        "status": "ok",
        "score": 40,
        "label": "elevated",
        "previous_score": null,
        "change": null,
        "trend": "escalating",
        "trend_basis": "input_trends",
        "summary": "Company drug safety for Eli Lilly and Co.: 40/100, elevated, trend escalating (from its inputs' latest moves). Strongest input: Drug recalls naming Eli Lilly, weekly at 50; weakest: FAERS adverse event reports for Eli Lilly products, weekly at 27. Based on 3 of 3 inputs.",
        "scale": {
          "high": "60+ = calm",
          "mid": "41-59 = normal",
          "low": "40 or less = elevated",
          "note": "Higher score means calmer than usual for this company: fewer recalls and adverse event reports, more approvals. Label changes are a watch item."
        },
        "drivers": [
          {
            "series_id": "openfda:LLY:adverse_event_reports_weekly",
            "label": "FAERS adverse event reports for Eli Lilly products, weekly",
            "score": 27,
            "summary": "FAERS adverse event reports for Eli Lilly products, weekly (lly) was 2302.0 count as of 2026-06-22, up 34.0% over 30 days. That level sits at the 79th percentile of the trailing window (z +0.65, 42 points). Composite 27/100 (higher reads weaker, so the score is inverted). Source openFDA (drug enforcement, drugs@FDA, FAERS); freshness 0/100.",
            "citation_url": "https://api.fda.gov/drug/event.json?search=receivedate:[20250901+TO+20261006]+AND+patient.drug.openfda.manufacturer_name:\"Eli+Lilly\"&count=receivedate"
          },
          {
            "series_id": "openfda:LLY:approvals_weekly",
            "label": "Original FDA approvals (NDA, BLA, ANDA) for Eli Lilly, weekly",
            "score": 48,
            "summary": "Original FDA approvals (NDA, BLA, ANDA) for Eli Lilly, weekly (lly) was 0.0000 count as of 2026-09-28, down 100.0% over 365 days. That level sits at the 48th percentile of the trailing window (z -0.20, 52 points). Composite 48/100 (higher reads stronger). Source openFDA (drug enforcement, drugs@FDA, FAERS); freshness 100/100.",
            "citation_url": "https://api.fda.gov/drug/drugsfda.json?search=submissions.submission_type:\"ORIG\"+AND+submissions.submission_status:\"AP\""
          },
          {
            "series_id": "openfda:LLY:drug_recalls_weekly",
            "label": "Drug recalls naming Eli Lilly, weekly",
            "score": 50,
            "summary": "Drug recalls naming Eli Lilly, weekly (lly) was 0.0000 count as of 2026-09-28. That level sits at the 50th percentile of the trailing window (z +0.00, 52 points). Composite 50/100 (higher reads weaker, so the score is inverted). Source openFDA (drug enforcement, drugs@FDA, FAERS); freshness 100/100.",
            "citation_url": "https://api.fda.gov/drug/enforcement.json?search=report_date:[20250831+TO+20261005]+AND+recalling_firm:\"Eli+Lilly\"&count=report_date"
          }
        ],
        "risk_flags": [
          "stale_data"
        ],
        "confidence": {
          "score": 82,
          "label": "high"
        },
        "coverage": {
          "scored": 3,
          "inputs": 3,
          "weight_share": 1
        },
        "inputs": [
          {
            "series_id": "openfda:LLY:drug_recalls_weekly",
            "label": "Drug recalls naming Eli Lilly, weekly",
            "entity_id": "lly",
            "weight": 2,
            "direction": -1,
            "value": {
              "current": 0,
              "unit": "count",
              "as_of": "2026-09-28",
              "transformed": 0
            },
            "changes_pct": {
              "7d": null,
              "30d": null,
              "90d": null,
              "365d": null
            },
            "hub_trend": "flat",
            "confidence": {
              "score": 96,
              "label": "high"
            },
            "risk_flags": [
              "single_source"
            ],
            "summary": "Drug recalls naming Eli Lilly, weekly (lly) was 0.0000 count as of 2026-09-28. That level sits at the 50th percentile of the trailing window (z +0.00, 52 points). Composite 50/100 (higher reads weaker, so the score is inverted). Source openFDA (drug enforcement, drugs@FDA, FAERS); freshness 100/100.",
            "citation_url": "https://api.fda.gov/drug/enforcement.json?search=report_date:[20250831+TO+20261005]+AND+recalling_firm:\"Eli+Lilly\"&count=report_date",
            "source": "openfda",
            "role": "input",
            "scoring": "hub_composite",
            "score": 50,
            "previous_score": null
          },
          {
            "series_id": "openfda:LLY:adverse_event_reports_weekly",
            "label": "FAERS adverse event reports for Eli Lilly products, weekly",
            "entity_id": "lly",
            "weight": 2,
            "direction": -1,
            "value": {
              "current": 2302,
              "unit": "count",
              "as_of": "2026-06-22",
              "transformed": 2302
            },
            "changes_pct": {
              "7d": 2.8138,
              "30d": 33.993,
              "90d": 5.8878,
              "365d": null
            },
            "hub_trend": "up",
            "confidence": {
              "score": 61,
              "label": "medium"
            },
            "risk_flags": [
              "stale_data",
              "revised_by_source",
              "single_source"
            ],
            "summary": "FAERS adverse event reports for Eli Lilly products, weekly (lly) was 2302.0 count as of 2026-06-22, up 34.0% over 30 days. That level sits at the 79th percentile of the trailing window (z +0.65, 42 points). Composite 27/100 (higher reads weaker, so the score is inverted). Source openFDA (drug enforcement, drugs@FDA, FAERS); freshness 0/100.",
            "citation_url": "https://api.fda.gov/drug/event.json?search=receivedate:[20250901+TO+20261006]+AND+patient.drug.openfda.manufacturer_name:\"Eli+Lilly\"&count=receivedate",
            "source": "openfda",
            "role": "input",
            "scoring": "hub_composite",
            "score": 27,
            "previous_score": null
          },
          {
            "series_id": "openfda:LLY:approvals_weekly",
            "label": "Original FDA approvals (NDA, BLA, ANDA) for Eli Lilly, weekly",
            "entity_id": "lly",
            "weight": 1,
            "direction": 1,
            "value": {
              "current": 0,
              "unit": "count",
              "as_of": "2026-09-28",
              "transformed": 0
            },
            "changes_pct": {
              "7d": -100,
              "30d": null,
              "90d": null,
              "365d": -100
            },
            "hub_trend": "flat",
            "confidence": {
              "score": 96,
              "label": "high"
            },
            "risk_flags": [
              "single_source"
            ],
            "summary": "Original FDA approvals (NDA, BLA, ANDA) for Eli Lilly, weekly (lly) was 0.0000 count as of 2026-09-28, down 100.0% over 365 days. That level sits at the 48th percentile of the trailing window (z -0.20, 52 points). Composite 48/100 (higher reads stronger). Source openFDA (drug enforcement, drugs@FDA, FAERS); freshness 100/100.",
            "citation_url": "https://api.fda.gov/drug/drugsfda.json?search=submissions.submission_type:\"ORIG\"+AND+submissions.submission_status:\"AP\"",
            "source": "openfda",
            "role": "input",
            "scoring": "hub_composite",
            "score": 48,
            "previous_score": null
          }
        ],
        "watch": [
          {
            "series_id": "openfda:LLY:label_updates_weekly",
            "label": "Drug label (SPL) versions effective for Eli Lilly products, weekly",
            "entity_id": "lly",
            "weight": 1,
            "direction": 0,
            "value": {
              "current": 0,
              "unit": "count",
              "as_of": "2026-09-28",
              "transformed": 0
            },
            "changes_pct": {
              "7d": null,
              "30d": -100,
              "90d": -100,
              "365d": null
            },
            "hub_trend": "down",
            "confidence": {
              "score": 96,
              "label": "high"
            },
            "risk_flags": [
              "sharp_move",
              "single_source"
            ],
            "summary": "Drug label (SPL) versions effective for Eli Lilly products, weekly (lly) was 0.0000 count as of 2026-09-28, down 100.0% over 30 days. That level sits at the 36th percentile of the trailing window (z -0.42, 52 points). Composite 56/100 (neutral series: the score measures how unusual the reading is). Source openFDA (drug enforcement, drugs@FDA, FAERS); freshness 100/100.",
            "citation_url": "https://api.fda.gov/drug/label.json?search=effective_time:[20250831+TO+20261005]+AND+openfda.manufacturer_name:\"Eli+Lilly\"&count=effective_time",
            "source": "openfda",
            "role": "watch",
            "scoring": "hub_unusualness",
            "score": 56,
            "previous_score": null
          }
        ],
        "citations": [
          {
            "series_id": "openfda:LLY:drug_recalls_weekly",
            "label": "Drug recalls naming Eli Lilly, weekly",
            "as_of": "2026-09-28",
            "url": "https://api.fda.gov/drug/enforcement.json?search=report_date:[20250831+TO+20261005]+AND+recalling_firm:\"Eli+Lilly\"&count=report_date",
            "source": "openfda"
          },
          {
            "series_id": "openfda:LLY:adverse_event_reports_weekly",
            "label": "FAERS adverse event reports for Eli Lilly products, weekly",
            "as_of": "2026-06-22",
            "url": "https://api.fda.gov/drug/event.json?search=receivedate:[20250901+TO+20261006]+AND+patient.drug.openfda.manufacturer_name:\"Eli+Lilly\"&count=receivedate",
            "source": "openfda"
          },
          {
            "series_id": "openfda:LLY:approvals_weekly",
            "label": "Original FDA approvals (NDA, BLA, ANDA) for Eli Lilly, weekly",
            "as_of": "2026-09-28",
            "url": "https://api.fda.gov/drug/drugsfda.json?search=submissions.submission_type:\"ORIG\"+AND+submissions.submission_status:\"AP\"",
            "source": "openfda"
          },
          {
            "series_id": "openfda:LLY:label_updates_weekly",
            "label": "Drug label (SPL) versions effective for Eli Lilly products, weekly",
            "as_of": "2026-09-28",
            "url": "https://api.fda.gov/drug/label.json?search=effective_time:[20250831+TO+20261005]+AND+openfda.manufacturer_name:\"Eli+Lilly\"&count=effective_time",
            "source": "openfda"
          }
        ],
        "method": {
          "version": "pmic-vertical/1.0",
          "docs": "https://github.com/organiccryptoyyc/pocket-agentic-services/blob/main/pmic/packs/README.md"
        },
        "recent_events": [
          {
            "source_id": "ctgov",
            "entity_id": "lly",
            "event_type": "trial_stopped",
            "event_time": "2026-09-23",
            "title": "terminated trial NCT06220669: A Study of LY3541860 in Adult Participants With Relapsing Multiple Sclerosis",
            "severity": "low",
            "source_url": "https://clinicaltrials.gov/study/NCT06220669",
            "fetch_time": "2026-10-04T21:19:43.127Z",
            "detail": {
              "nct_id": "NCT06220669",
              "status": "TERMINATED",
              "phases": [
                "PHASE2"
              ]
            }
          },
          {
            "source_id": "openfda",
            "entity_id": "lly",
            "event_type": "drug_approval",
            "event_time": "2026-09-23",
            "title": "Original approval of ONSWIK (BLA761408) for ELI LILLY AND CO",
            "severity": "medium",
            "source_url": "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=761408",
            "fetch_time": "2026-10-04T15:01:55.799Z",
            "detail": {
              "application_number": "BLA761408",
              "sponsor_name": "ELI LILLY AND CO",
              "brand_name": "ONSWIK",
              "review_priority": "STANDARD",
              "submission_class": "Type 1 - New Molecular Entity"
            }
          },
          {
            "source_id": "sec",
            "entity_id": "lly",
            "event_type": "insider_form4",
            "event_time": "2026-09-22",
            "title": "4 filed 2026-09-22 for period 2026-09-21",
            "severity": "low",
            "source_url": "https://www.sec.gov/Archives/edgar/data/59478/000131021526000017/xslF345X06/wk-form4_1790107902.xml",
            "fetch_time": "2026-10-04T15:01:55.799Z",
            "detail": {
              "form": "4",
              "items": null,
              "report_date": "2026-09-21",
              "primary_document": "xslF345X06/wk-form4_1790107902.xml",
              "cik": 59478
            }
          },
          {
            "source_id": "sec",
            "entity_id": "lly",
            "event_type": "insider_form4",
            "event_time": "2026-09-22",
            "title": "4 filed 2026-09-22 for period 2026-09-21",
            "severity": "low",
            "source_url": "https://www.sec.gov/Archives/edgar/data/59478/000005947826000089/xslF345X06/wk-form4_1790107969.xml",
            "fetch_time": "2026-10-04T15:01:55.799Z",
            "detail": {
              "form": "4",
              "items": null,
              "report_date": "2026-09-21",
              "primary_document": "xslF345X06/wk-form4_1790107969.xml",
              "cik": 59478
            }
          },
          {
            "source_id": "sec",
            "entity_id": "lly",
            "event_type": "insider_form4",
            "event_time": "2026-09-22",
            "title": "4 filed 2026-09-22 for period 2026-09-21",
            "severity": "low",
            "source_url": "https://www.sec.gov/Archives/edgar/data/59478/000005947826000091/xslF345X06/wk-form4_1790108065.xml",
            "fetch_time": "2026-10-04T15:01:55.799Z",
            "detail": {
              "form": "4",
              "items": null,
              "report_date": "2026-09-21",
              "primary_document": "xslF345X06/wk-form4_1790108065.xml",
              "cik": 59478
            }
          },
          {
            "source_id": "sec",
            "entity_id": "lly",
            "event_type": "insider_form4",
            "event_time": "2026-09-22",
            "title": "4 filed 2026-09-22 for period 2026-09-21",
            "severity": "low",
            "source_url": "https://www.sec.gov/Archives/edgar/data/59478/000126238826000018/xslF345X06/wk-form4_1790108122.xml",
            "fetch_time": "2026-10-04T15:01:55.799Z",
            "detail": {
              "form": "4",
              "items": null,
              "report_date": "2026-09-21",
              "primary_document": "xslF345X06/wk-form4_1790108122.xml",
              "cik": 59478
            }
          },
          {
            "source_id": "ctgov",
            "entity_id": "lly",
            "event_type": "trial_stopped",
            "event_time": "2026-09-21",
            "title": "terminated trial NCT07085468: A Study of LY3549492 in Healthy Weight Adult Participants",
            "severity": "low",
            "source_url": "https://clinicaltrials.gov/study/NCT07085468",
            "fetch_time": "2026-10-04T21:19:43.127Z",
            "detail": {
              "nct_id": "NCT07085468",
              "status": "TERMINATED",
              "phases": [
                "PHASE2"
              ]
            }
          },
          {
            "source_id": "ctgov",
            "entity_id": "lly",
            "event_type": "trial_stopped",
            "event_time": "2026-09-14",
            "title": "terminated trial NCT07152002: A Study of LY4064912 in Healthy Participants and With Overweight or Obesity",
            "severity": "low",
            "source_url": "https://clinicaltrials.gov/study/NCT07152002",
            "fetch_time": "2026-10-04T21:19:43.127Z",
            "detail": {
              "nct_id": "NCT07152002",
              "status": "TERMINATED",
              "phases": [
                "PHASE1"
              ]
            }
          },
          {
            "source_id": "sec",
            "entity_id": "lly",
            "event_type": "insider_form4",
            "event_time": "2026-09-11",
            "title": "4 filed 2026-09-11 for period 2025-09-22",
            "severity": "low",
            "source_url": "https://www.sec.gov/Archives/edgar/data/59478/000203208926000004/xslF345X06/wk-form4_1789157763.xml",
            "fetch_time": "2026-10-04T15:01:55.799Z",
            "detail": {
              "form": "4",
              "items": null,
              "report_date": "2025-09-22",
              "primary_document": "xslF345X06/wk-form4_1789157763.xml",
              "cik": 59478
            }
          },
          {
            "source_id": "ctgov",
            "entity_id": "lly",
            "event_type": "trial_stopped",
            "event_time": "2026-09-09",
            "title": "terminated trial NCT06916143: Comparing the Extent to Which Three Different Formulations of LY4100511 (DC-853) Are Made Available in the Body, Alone and in the Presence of a Drug That Reduce",
            "severity": "low",
            "source_url": "https://clinicaltrials.gov/study/NCT06916143",
            "fetch_time": "2026-10-04T21:19:43.127Z",
            "detail": {
              "nct_id": "NCT06916143",
              "status": "TERMINATED",
              "phases": [
                "PHASE1"
              ]
            }
          },
          {
            "source_id": "ctgov",
            "entity_id": "lly",
            "event_type": "trial_stopped",
            "event_time": "2026-09-08",
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